More than 400 randomized controlled clinical trials (RCTs) of antipsychotic efficacy have been conducted, finding generally moderate effect sizes of antipsychotic drugs compared to placebo. For comparison, RCTs of various general medicine drugs, used on their respective indications, demonstrate similar effect sizes. Nevertheless, claims about limited efficacy of antipsychotics have been put forward. Pertinent questions remain: are the effect sizes clinically meaningful and ge